February 16, 2019

Superbugs will ‘kill every three seconds’


Superbugs will kill someone every three seconds by 2050 unless the world acts now, a hugely influential report says.
The global review sets out a plan for preventing medicine “being cast back into the dark ages” that requires billions of dollars of investment.
It also calls for a revolution in the way antibiotics are used and a massive campaign to educate people.
The report has received a mixed response with some concerned that it does not go far enough.
The battle against infections that are resistant to drugs is one the world is losing rapidly and has been described as “as big a risk as terrorism”.
The problem is that we are simply not developing enough new antibiotics and we are wasting the ones we have.
Since the Review on Antimicrobial Resistance started in mid-2014, more than one million people have died from such infections.
And in that time doctors also discovered bacteria that can shrug off the drug of last resort – colistin – leading to warnings that the world was teetering on the cusp of a “post-antibiotic era”.
The review says the situation will get only worse with 10 million people predicted to die every year from resistant infections by 2050.
And the financial cost to economies of drug resistance will add up to $100 trillion (£70 trillion) by the mid-point of the century.

An urgent and massive global awareness campaign as most people are ignorant of the risks
Establishing a $2bn ($1.4bn) Global Innovation Fund for early stage research
Improved access to clean water, sanitation and cleaner hospitals to prevent infections spreading
Reduce the unnecessary vast antibiotic use in agriculture including a ban on those “highly critical” to human health
Improved surveillance of the spread of drug resistance

Financial incentives to develop new tests to prevent antibiotics being given when they will not work
Promoting the use of vaccines and alternatives to drugs
The review said the economic case for action “was clear” and could be paid for using a small cut of the current health budgets of countries or through extra taxes on pharmaceutical companies not investing in antibiotic research.
Lord Jim O’Neill, the economist who led the global review, told the BBC: “We need to inform in different ways, all over the world, why it’s crucial we stop treating our antibiotics like sweets.
“If we don’t solve the problem we are heading to the dark ages, we will have a lot of people dying.
“We have made some pretty challenging recommendations which require everybody to get out of the comfort zone, because if we don’t then we aren’t going to be able to solve this problem.”
A terrible future could be on the horizon, a future which rips one of the greatest tools of medicine out of the hands of doctors.
A simple cut to your finger could leave you fighting for your life. Luck will play a bigger role in your future than any doctor could.
The most basic operations – getting an appendix removed or a hip replacement – could become deadly.
Cancer treatments and organ transplants could kill you. Childbirth could once again become a deadly moment in a woman’s life.
It’s a future without antibiotics.
This might read like the plot of a science fiction novel – but there is genuine fear that the world is heading into a post-antibiotic era.
It is hoped the measures will prevent more people going through experiences like Emily Morris from Milton Keynes.
She has regular urinary tract infections that do not respond to some antibiotics and could cause kidney damage or even death.
She says: “With every sting and every pain, my heart sinks at the thought of how many antibiotics I have left to use this time.
Pharma challenge
Chancellor George Osborne said: “Apart from the moral case for action, the economic cost of failing to act is too great to contemplate.
“So I am calling on other finance ministries to come together this year and, working with industry leaders and medical experts, agree a common approach.”
Exactly how to encourage the drugs industry to make new antibiotics has been a long running problem – there has not been a new class of antibiotics discovered since the 1980s.
A new antibiotic would be kept on the shelf for use in emergencies so a company could never make back its huge research and development costs.
John Rex, from the antibiotics unit at AstraZeneca, said a new way of paying for drugs, as proposed in the report, was needed.
He argued: “Such models should recognise antibiotics as the healthcare equivalent of the fire extinguisher – they must be available on the wall at all times and have value even when used only infrequently.”
Lord O’Neill also focused criticism on agricultural practices that use antibiotics to boost the growth of animals, rather than to treat their infections.
In the US, 70% of antibiotics (sold by weight) are for use in animals.
Despite being in animals, the practice risks spreading bacterial drug resistance to human infections as was witnessed with colisitin resistance last year.

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